"Kim Stanley Robinson - Forty Signs of Rain" - читать интересную книгу автора (Robinson Kim Stanley)тАЬOr hepatocytes?тАЭ тАЬUptake is in blood.тАЭ тАЬWhat we need is to package the inserts with a ligand that is really specific for the target cells. If we could find that specificity, out of all the possible proteins, without going through all the rigamarole of trial and errorтАжтАЭ тАЬToo bad we donтАЩt still have Pierzinski here. He could run the array of possibilities through his operation set.тАЭ тАЬWell, we could call him up and ask him to give it a try.тАЭ тАЬSure, but whoтАЩs got time for that kind of thing?тАЭ тАЬHeтАЩs still working on a paper with Eleanor over on campus,тАЭ Marta said, meaning UCSD. тАЬIтАЩll ask him when he comes down.тАЭ Brian said, almost as if joking, тАЬMaybe you could try to make the insertion in a limb, away from the organs. Tourniquet a lower leg or a forearm, blow it up with the full dose, wait for it to permeate the endothelial cells lining the veins and arteries in the limb, then release the tourniquet. TheyтАЩd pee off the extra water, and still have a certain number of altered cells. It wouldnтАЩt be any worse than chugging a few beers, would it?тАЭ тАЬBig fucking deal.тАЭ тАЬYou might get phlebitis if it was your leg. IsnтАЩt that how it happens?тАЭ тАЬWell use the hand then.тАЭ тАЬInteresting,тАЭ Leo said. тАЬHeck, letтАЩs try it at least. The other options look worse to me. Although we should probably try the mice on the various limits on volume and dosage in the original experiment, just to be sure.тАЭ So the meeting petered out, and they wandered off to go home, or back to their desks and benches, thinking over plans for more experiments. Getting the mice, getting the time on the machines, sequencing genes, sequencing schedules; when you were doing science the hours flew by, and the days, and the weeks. This was the main feeling: there was never enough time to do it all. Was this different from other kinds of work? Papers almost written were rewritten, checked, rewritten againтАФfinally sent off. Papers with their problems papered over. Lots of times the lab was like some old-fashioned newspaper office with a deadline approaching, all the starving journalists churning out the next dayтАЩs fishwrap. Except people would not wrap fish with these papers; they would save them, file them by category, test all their assertions, cite themтАФand report any errors to the authorities. LeoтАЩsTHINGS TO DO list grew and shrank, grew and shrank, grew and then refused to shrink. He spent much less time than he wanted to at home in Leucadia with Roxanne. Roxanne understood, but it bothered him, even if it didnтАЩt bother her. |
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